Publications
Image: Hyunju Oh-Strauß: Confocal immunofluorescence of c-Rel nuclear presence in Germinal Center B Cells
Selected Publications
Kober-Hasslacher M, Oh-Strauß H, Kumar D, Soberón V, Diehl C, Lech M, Engleitner T, Katab E, Fernandez Saiz V, Piontek G, Li H, Menze B, Ziegenhain C, Enard W, Rad R, Böttcher JP, Anders HJ, Rudelius M, Schmidt-Supprian M. c-Rel gain in B cells drives germinal center reactions and autoantibody production. J Clin Invest. 2020 May 18:124382. doi: 10.1172/JCI124382. (link is external)
Vahl JC, Drees C, Heger K, Heink S, Fischer JC, Nedjic J, Ohkura N, Morikawa H, Poeck H, Schallenberg S, Rieß D, Hein MY, Buch T, Polic B, Schönle A, Zeiser R, Schmitt-Gräff A, Kretschmer K, Klein L, Korn T, Sakaguchi S, Schmidt-Supprian M. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity. 2014 Nov 20;41(5):722-36. doi: 10.1016/j.immuni.2014.10.012 (link is external).
Heger K, Fierens K, Vahl JC, Aszodi A, Peschke K, Schenten D, Hammad H, Beyaert R, Saur D, van Loo G, Roers A, Lambrecht BN, Kool M, Schmidt-Supprian M. A20-deficient mast cells exacerbate inflammatory responses in vivo. PLoS Biol. 2014 Jan;12(1):e1001762. doi: 10.1371/journal.pbio.1001762 (link is external).
Vahl JC, Heger K, Knies N, Hein MY, Boon L, Yagita H, Polic B, Schmidt-Supprian M. NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology. PLoS Biol. 2013;11(6):e1001589. doi: 10.1371/journal.pbio.1001589 (link is external).
Bertossi A, Aichinger M, Sansonetti P, Lech M, Neff F, Pal M, Wunderlich FT, Anders HJ, Klein L, Schmidt-Supprian M. Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med. 2011 Aug 29;208(9):1749-56. doi: 10.1084/jem.20110578 (link is external).
Chu Y, Vahl JC, Kumar D, Heger K, Bertossi A, Wójtowicz E, Soberon V, Schenten D, Mack B, Reutelshöfer M, Beyaert R, Amann K, van Loo G, Schmidt-Supprian M. B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. Blood. 2011 Feb 17;117(7):2227-36. doi: 10.1182/blood-2010-09-306019 (link is external).
All publications
Bararia D, Hildebrand JA, Stolz S, Haebe S, Alig S, Trevisani CP, Osorio- Barrios F, Bartoschek MD, Mentz M, Pastore A, Gaitzsch E, Heide M, Jurinovic V, Rautter K, Gunawardana J, Sabdia MB, Szczepanowski M, Richter J, Klapper W, Louissaint A Jr, Ludwig C, Bultmann S, Leonhardt H, Eustermann S, Hopfner KP, Hiddemann W, von Bergwelt-Baildon M, Steidl C, Kridel R, Tobin JWD, Gandhi MK, Weinstock DM, Schmidt-Supprian M, Sárosi MB, Rudelius M, Passerini V, Mautner J, Weigert O. Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma. Cell Rep. 2020 May 5;31(5):107522. doi: 10.1016/j.celrep.2020.107522 . Epub 2020 Apr 23. PMID: 32330423 .
Kober-Hasslacher M, Oh-Strauß H, Kumar D, Soberón V, Diehl C, Lech M, Engleitner T, Katab E, Fernandez Saiz V, Piontek G, Li H, Menze B, Ziegenhain C, Enard W, Rad R, Böttcher JP, Anders HJ, Rudelius M, Schmidt-Supprian M. c-Rel gain in B cells drives germinal center reactions and autoantibody production. J Clin Invest. 2020 Mar 19. pii: 124382. doi: 10.1172/JCI124382 . [Epub ahead of print] PubMed PMID: 32191641 .
Jiang Y, Müller K, Khan MA, Assmann JC, Lampe J, Kilau K, Richter M, Kleint M, Ridder DA, Hübner N, Schmidt-Supprian M, Wenzel J, Schwaninger M. Cerebral angiogenesis ameliorates pathological disorders in Nemo-deficient mice with small-vessel disease. J Cereb Blood Flow Metab. 2020 Mar 9:271678X20910522. doi: 10.1177/0271678X20910522 . [Epub ahead of print] PubMed PMID: 32151223.
Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-Supprian M, Frietze S, Ringshausen I. Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance. Sci Transl Med. 2020 Jan 15;12(526). pii: eaax9340. doi: 10.1126/scitranslmed.aax9340 . PubMed PMID: 31941829 .
Kober-Hasslacher M, Schmidt-Supprian M. The Unsolved Puzzle of c-Rel in B Cell Lymphoma. Cancers (Basel). 2019 Jul 4;11(7). pii: E941. doi: 10.3390/cancers11070941 . Review. PubMed PMID: 31277480 ; PubMed Central PMCID: PMC6678315.
Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz I, Ravens S. Single-Cell Transcriptomics Identifies the Adaptation of Scart1(+) Vγ6(+) T Cells to Skin Residency as Activated Effector Cells. Cell Rep. 2019 Jun 18;27(12):3657-3671.e4. doi: 10.1016/j.celrep.2019.05.064 . PubMed PMID: 31216482 .
Dashtsoodol N, Bortoluzzi S, Schmidt-Supprian M. T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells. Front Immunol. 2019 Apr 26;10:841. doi: 10.3389/fimmu.2019.00841 . eCollection 2019. Review. PubMed PMID: 31080448 ; PubMed Central PMCID: PMC6497757.
Sperling S, Fiedler P, Lechner M, Pollithy A, Ehrenberg S, Schiefer AI, Kenner L, Feuchtinger A, Kühn R, Swinerd G, Schmidt-Supprian M, Strobl LJ, Zimber-Strobl U. Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells. Blood. 2019 Jun 13;133(24):2597-2609. doi: 10.1182/blood.2018880138 . Epub 2019 Apr 8. PubMed PMID: 30962205
Weber J, de la Rosa J, Grove CS, Schick M, Rad L, Baranov O, Strong A, Pfaus A, Friedrich MJ, Engleitner T, Lersch R, Öllinger R, Grau M, Menendez IG, Martella M, Kohlhofer U, Banerjee R, Turchaninova MA, Scherger A, Hoffman GJ, Hess J, Kuhn LB, Ammon T, Kim J, Schneider G, Unger K, Zimber-Strobl U, Heikenwälder M, Schmidt-Supprian M, Yang F, Saur D, Liu P, Steiger K, Chudakov DM, Lenz G, Quintanilla-Martinez L, Keller U, Vassiliou GS, Cadiñanos J, Bradley A, Rad R. PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice. Nat Commun. 2019 Mar 29;10(1):1415. doi: 10.1038/s41467-019-09180-3 . PubMed PMID: 30926791 ; PubMed Central PMCID: PMC6440946.
Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G, Klein-Hitpass L, Williamson JC, Lehner PJ, Dürig J, Möllmann M, Rásó-Barnett L, Hughes K, Santoro A, Méndez-Ferrer S, Oostendorp RAJ, Zimber-Strobl U, Peschel C, Hodson DJ, Schmidt-Supprian M, Ringshausen I. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018 Sep 21;9(1):3839. doi: 10.1038/s41467-018-06069-5 . PubMed PMID: 30242258 ; PubMed Central PMCID: PMC6155045.
Fischer JC, Otten V, Kober M, Drees C, Rosenbaum M, Schmickl M, Heidegger S, Beyaert R, van Loo G, Li XC, Peschel C, Schmidt-Supprian M, Haas T, Spoerl S, Poeck H. A20 Restrains Thymic Regulatory T Cell Development. J Immunol. 2017 Oct 1;199(7):2356-2365. doi: 10.4049/jimmunol.1602102. Epub 2017 Aug 25. PubMed PMID: 28842469; PubMed Central PMCID: PMC5617121.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T. Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T(H)17 cells. Nat Immunol. 2017 Mar 22;18(4):474. doi: 10.1038/ni0417-474b. PubMed PMID: 28323263.
Schneider G, Schmidt-Supprian M, Rad R, Saur D. Tissue-specific tumorigenesis: context matters. Nat Rev Cancer. 2017 Apr;17(4):239-253. doi: 10.1038/nrc.2017.5. Epub 2017 Mar 3. Review. PubMed PMID: 28256574; PubMed Central PMCID: PMC5823237.
Drees C, Vahl JC, Bortoluzzi S, Heger KD, Fischer JC, Wunderlich FT, Peschel C, Schmidt-Supprian M. Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets. J Immunol. 2017 Apr 1;198(7):2747-2759. doi: 10.4049/jimmunol.1601732. Epub 2017 Feb 10. PubMed PMID: 28188245.
Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY. Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. J Exp Med. 2017 Mar 6;214(3):609-622. doi: 10.1084/jem.20161318. Epub 2017 Jan 27. PubMed PMID: 28130403; PubMed Central PMCID: PMC5339675.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T(H)17 cells. Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28. Erratum in: Nat Immunol. 2017 Mar 22;18(4):474. PubMed PMID: 27893700; PubMed Central PMCID: PMC5164931.
Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. K(+) Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27. PubMed PMID: 27692612.
Derudder E, Herzog S, Labi V, Yasuda T, Köchert K, Janz M, Villunger A, Schmidt-Supprian M, Rajewsky K. Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells. Proc Natl Acad Sci U S A. 2016 May 3;113(18):5065-70. doi: 10.1073/pnas.1604529113. Epub 2016 Apr 20. PubMed PMID: 27099294; PubMed Central PMCID: PMC4983837.
Meininger I, Griesbach RA, Hu D, Gehring T, Seeholzer T, Bertossi A, Kranich J, Oeckinghaus A, Eitelhuber AC, Greczmiel U, Gewies A, Schmidt-Supprian M, Ruland J, Brocker T, Heissmeyer V, Heyd F, Krappmann D. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells. Nat Commun. 2016 Apr 12;7:11292. doi: 10.1038/ncomms11292. PubMed PMID: 27068814; PubMed Central PMCID: PMC4832065.
Ridder DA, Wenzel J, Müller K, Töllner K, Tong XK, Assmann JC, Stroobants S, Weber T, Niturad C, Fischer L, Lembrich B, Wolburg H, Grand'Maison M, Papadopoulos P, Korpos E, Truchetet F, Rades D, Sorokin LM, Schmidt-Supprian M, Bedell BJ, Pasparakis M, Balschun D, D'Hooge R, Löscher W, Hamel E, Schwaninger M. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. J Exp Med. 2015 Sep 21;212(10):1529-49. doi: 10.1084/jem.20150165. Epub 2015 Sep 7. PubMed PMID: 26347470; PubMed Central PMCID: PMC4577837.
Drees C, Vahl JC, Schmidt-Supprian M. TCR signals fuel Treg cells. Oncotarget. 2015 Sep 8;6(26):21773-4. PubMed PMID: 26318042; PubMed Central PMCID: PMC4673113.
Deeb SJ, Tyanova S, Hummel M, Schmidt-Supprian M, Cox J, Mann M. Machine Learning-based Classification of Diffuse Large B-cell Lymphoma Patients by Their Protein Expression Profiles. Mol Cell Proteomics. 2015 Nov;14(11):2947-60. doi: 10.1074/mcp.M115.050245. Epub 2015 Aug 26. PubMed PMID: 26311899; PubMed Central PMCID: PMC4638038.
Murakawa Y, Hinz M, Mothes J, Schuetz A, Uhl M, Wyler E, Yasuda T, Mastrobuoni G, Friedel CC, Dölken L, Kempa S, Schmidt-Supprian M, Blüthgen N, Backofen R, Heinemann U, Wolf J, Scheidereit C, Landthaler M. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway. Nat Commun. 2015 Jul 14;6:7367. doi: 10.1038/ncomms8367. PubMed PMID: 26170170; PubMed Central PMCID: PMC4510711.
Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E. γ-Secretase directly sheds the survival receptor BCMA from plasma cells. Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333. PubMed PMID: 26065893; PubMed Central PMCID: PMC4490565.
Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, Rajewsky K. An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression. Cell Rep. 2015 May 5;11(5):715-26. doi: 10.1016/j.celrep.2015.03.059. Epub 2015 Apr 23. PubMed PMID: 25921526; PubMed Central PMCID: PMC4426003.
Heger K, Kober M, Rieß D, Drees C, de Vries I, Bertossi A, Roers A, Sixt M, Schmidt-Supprian M. A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors. Eur J Immunol. 2015 Jun;45(6):1614-20. doi: 10.1002/eji.201545457. Epub 2015 Apr 17. PubMed PMID: 25787118.
Vahl JC, Drees C, Heger K, Heink S, Fischer JC, Nedjic J, Ohkura N, Morikawa H, Poeck H, Schallenberg S, Rieß D, Hein MY, Buch T, Polic B, Schönle A, Zeiser R, Schmitt-Gräff A, Kretschmer K, Klein L, Korn T, Sakaguchi S, Schmidt-Supprian M. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity. 2014 Nov 20;41(5):722-36. doi: 10.1016/j.immuni.2014.10.012. Epub 2014 Nov 6. PubMed PMID: 25464853.
Förster A, Blissenbach B, Machova A, Leja S, Rabenhorst A, Wilmschen S, Heger K, Schmidt-Supprian M, Roers A, Hartmann K, Papadopoulou N. Dicer is indispensable for the development of murine mast cells. J Allergy Clin Immunol. 2015 Apr;135(4):1077-80.e4. doi: 10.1016/j.jaci.2014.10.005. Epub 2014 Oct 30. PubMed PMID: 25457155.
Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brönneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brüning JC. Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. Cell Rep. 2014 Nov 20;9(4):1495-506. doi: 10.1016/j.celrep.2014.10.045. Epub 2014 Nov 13. PubMed PMID: 25456138.
Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U. GP130 activation induces myeloma and collaborates with MYC. J Clin Invest. 2014 Dec;124(12):5263-74. doi: 10.1172/JCI69094. Epub 2014 Nov 10. PubMed PMID: 25384216; PubMed Central PMCID: PMC4348946.
Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V. Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immunol. 2014 Nov;15(11):1079-89. doi: 10.1038/ni.3008. Epub 2014 Oct 5. PubMed PMID: 25282160.
Peschke K, Weitzmann A, Heger K, Behrendt R, Schubert N, Scholten J, Voehringer D, Hartmann K, Dudeck A, Schmidt-Supprian M, Roers A. IκB kinase 2 is essential for IgE-induced mast cell de novo cytokine production but not for degranulation. Cell Rep. 2014 Sep 11;8(5):1300-7. doi: 10.1016/j.celrep.2014.07.046. Epub 2014 Aug 28. PubMed PMID: 25176657.
Heger K, Fierens K, Vahl JC, Aszodi A, Peschke K, Schenten D, Hammad H, Beyaert R, Saur D, van Loo G, Roers A, Lambrecht BN, Kool M, Schmidt-Supprian M. A20-deficient mast cells exacerbate inflammatory responses in vivo. PLoS Biol. 2014 Jan;12(1):e1001762. doi: 10.1371/journal.pbio.1001762. Epub 2014 Jan 14. PubMed PMID: 24453940; PubMed Central PMCID: PMC3891641.
Yasuda T, Wirtz T, Zhang B, Wunderlich T, Schmidt-Supprian M, Sommermann T, Rajewsky K. Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. Cold Spring Harb Symp Quant Biol. 2013;78:259-63. doi: 10.1101/sqb.2013.78.020222 
. Epub 2013 Nov 15. PubMed PMID: 24241423 .
Deeb SJ, Cox J, Schmidt-Supprian M, Mann M. N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes. Mol Cell Proteomics. 2014 Jan;13(1):240-51. doi: 10.1074/mcp.M113.033977 . Epub 2013 Nov 4. PubMed PMID: 24190977 ; PubMed Central PMCID: PMC3879617.
Heger K, Seidler B, Vahl JC, Schwartz C, Kober M, Klein S, Voehringer D, Saur D, Schmidt-Supprian M. CreER(T2) expression from within the c-Kit gene locus allows efficient inducible gene targeting in and ablation of mast cells. Eur J Immunol. 2014 Jan;44(1):296-306. doi: 10.1002/eji.201343731 . Epub 2013 Oct 14. PubMed PMID: 24127407 .
Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, Rajewsky K, Koralov SB. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. J Immunol. 2013 Sep 15;191(6):3100-11. doi: 10.4049/jimmunol.1301360 . Epub 2013 Aug 21. Erratum in: J Immunol. 2013 Nov 15;191(10):5318. Casola, Stefano S [corrected to Casola, Stefano]. PubMed PMID: 23966625 ; PubMed Central PMCID: PMC3822005.
Vahl JC, Heger K, Knies N, Hein MY, Boon L, Yagita H, Polic B, Schmidt-Supprian M. NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology. PLoS Biol. 2013;11(6):e1001589. doi: 10.1371/journal.pbio.1001589 . Epub 2013 Jun 18. PubMed PMID: 23853545 ; PubMed Central PMCID: PMC3708704.
Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V. Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity. 2013 Apr 18;38(4):655-68. doi: 10.1016/j.immuni.2012.12.004 . Epub 2013 Apr 11. PubMed PMID: 23583643 .
Pal M, Wunderlich CM, Spohn G, Brönneke HS, Schmidt-Supprian M, Wunderlich FT. Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in mice. PLoS One. 2013;8(1):e54247. doi: 10.1371/journal.pone.0054247 . Epub 2013 Jan 17. PubMed PMID: 23349837 ; PubMed Central PMCID: PMC3547909.
Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ, Dürig J, Wagner M, Haferlach C, Kohlmann A, Schnittger S, Seifert M, Wanninger S, Zaborsky N, Oostendorp R, Ruland J, Leitges M, Kuhnt T, Schäfer Y, Lampl B, Peschel C, Egle A, Ringshausen I. Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell. 2013 Jan 14;23(1):77-92. doi: 10.1016/j.ccr.2012.12.003 . PubMed PMID: 23328482 ; PubMed Central PMCID: PMC3546417.
Chu Y, Soberon V, Glockner L, Beyaert R, Massoumi R, van Loo G, Krappmann D, Schmidt-Supprian M. A20 and CYLD do not share significant overlapping functions during B cell development and activation. J Immunol. 2012 Nov 1;189(9):4437-43. doi: 10.4049/jimmunol.1200396 . Epub 2012 Sep 21. PubMed PMID: 23002441 .
Deeb SJ, D'Souza RC, Cox J, Schmidt-Supprian M, Mann M. Super-SILAC allows classification of diffuse large B-cell lymphoma subtypes by their protein expression profiles. Mol Cell Proteomics. 2012 May;11(5):77-89. doi: 10.1074/mcp.M111.015362 . Epub 2012 Mar 21. PubMed PMID: 22442255 ; PubMed Central PMCID: PMC3418848.
Liu L, Abdel Motaal B, Schmidt-Supprian M, Pohl NL. Multigram synthesis of isobutyl-β-C-galactoside as a substitute of isopropylthiogalactoside for exogenous gene induction in mammalian cells. J Org Chem. 2012 Feb 3;77(3):1539-46. doi: 10.1021/jo2024569 . Epub 2012 Jan 24. PubMed PMID: 22283618 .
Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV Jr, Walther TC. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab. 2011 Oct 5;14(4):504-15. doi: 10.1016/j.cmet.2011.07.013 . PubMed PMID: 21982710 ; PubMed Central PMCID: PMC3735358.
Birbach A, Eisenbarth D, Kozakowski N, Ladenhauf E, Schmidt-Supprian M, Schmid JA. Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor model. Neoplasia. 2011 Aug;13(8):692-703. PubMed PMID: 21847361 ; PubMed Central PMCID: PMC3156660.
Bertossi A, Aichinger M, Sansonetti P, Lech M, Neff F, Pal M, Wunderlich FT, Anders HJ, Klein L, Schmidt-Supprian M. Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med. 2011 Aug 29;208(9):1749-56. doi: 10.1084/jem.20110578 . Epub 2011 Aug 15. PubMed PMID: 21844204 ; PubMed Central PMCID: PMC3171092.
Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Mc Guire C, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet. 2011 Aug 14;43(9):908-12. doi: 10.1038/ng.874 . PubMed PMID: 21841782 .
Hofmann J, Mair F, Greter M, Schmidt-Supprian M, Becher B. NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. J Exp Med. 2011 Aug 29;208(9):1917-29. doi: 10.1084/jem.20110128 . Epub 2011 Aug 1. PubMed PMID: 21807870 ; PubMed Central PMCID: PMC3171087.
Hampel F, Ehrenberg S, Hojer C, Draeseke A, Marschall-Schröter G, Kühn R, Mack B, Gires O, Vahl CJ, Schmidt-Supprian M, Strobl LJ, Zimber-Strobl U. CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling. Blood. 2011 Dec 8;118(24):6321-31. doi: 10.1182/blood-2010-12-325944 . Epub 2011 Jul 27. PubMed PMID: 21795747 .
Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M. Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J Clin Invest. 2011 Jul;121(7):2781-93. doi: 10.1172/JCI45349 . Epub 2011 Jun 23. PubMed PMID: 21701067 ; PubMed Central PMCID: PMC3223831.
Hadian K, Griesbach RA, Dornauer S, Wanger TM, Nagel D, Metlitzky M, Beisker W, Schmidt-Supprian M, Krappmann D. NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation. J Biol Chem. 2011 Jul 22;286(29):26107-17. doi: 10.1074/jbc.M111.233163 . Epub 2011 May 26. PubMed PMID: 21622571 ; PubMed Central PMCID: PMC3138271.
Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2873-8. doi: 10.1073/pnas.1019537108 . Epub 2011 Jan 31. PubMed PMID: 21282644 ; PubMed Central PMCID: PMC3041080.
Keren Z, Naor S, Nussbaum S, Golan K, Itkin T, Sasaki Y, Schmidt-Supprian M, Lapidot T, Melamed D. B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood. 2011 Mar 17;117(11):3104-12. doi: 10.1182/blood-2010-09-307983 . Epub 2011 Jan 12. PubMed PMID: 21228330 .
Calado DP, Zhang B, Srinivasan L, Sasaki Y, Seagal J, Unitt C, Rodig S, Kutok J, Tarakhovsky A, Schmidt-Supprian M, Rajewsky K. Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma. Cancer Cell. 2010 Dec 14;18(6):580-9. doi: 10.1016/j.ccr.2010.11.024 . PubMed PMID: 21156282 ; PubMed Central PMCID: PMC3018685.
Yang C, McCoy K, Davis JL, Schmidt-Supprian M, Sasaki Y, Faccio R, Novack DV. NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis. PLoS One. 2010 Nov 8;5(11):e15383. doi: 10.1371/journal.pone.0015383 . PubMed PMID: 21151480 ; PubMed Central PMCID: PMC2975662.
Chu Y, Vahl JC, Kumar D, Heger K, Bertossi A, Wójtowicz E, Soberon V, Schenten D, Mack B, Reutelshöfer M, Beyaert R, Amann K, van Loo G, Schmidt-Supprian M. B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. Blood. 2011 Feb 17;117(7):2227-36. doi: 10.1182/blood-2010-09-306019 . Epub 2010 Nov 18. PubMed PMID: 21088135 .
Vereecke L, Sze M, Mc Guire C, Rogiers B, Chu Y, Schmidt-Supprian M, Pasparakis M, Beyaert R, van Loo G. Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis. J Exp Med. 2010 Jul 5;207(7):1513-23. doi: 10.1084/jem.20092474 . Epub 2010 Jun 7. PubMed PMID: 20530205 ; PubMed Central PMCID: PMC2901067.
Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, Sasakawa C. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat Cell Biol. 2010 Jan;12(1):66-73; sup pp 1-9. doi: 10.1038/ncb2006 . Epub 2009 Dec 13. PubMed PMID: 20010814 ; PubMed Central PMCID: PMC3107189.
Derudder E, Cadera EJ, Vahl JC, Wang J, Fox CJ, Zha S, van Loo G, Pasparakis M, Schlissel MS, Schmidt-Supprian M, Rajewsky K. Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals. Nat Immunol. 2009 Jun;10(6):647-54. doi: 10.1038/ni.1732 . Epub 2009 May 3. PubMed PMID: 19412180 ; PubMed Central PMCID: PMC2742984.
Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K. BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12435-8. doi: 10.1073/pnas.0805460105 . Epub 2008 Aug 19. PubMed PMID: 18713867 ; PubMed Central PMCID: PMC2527929.
Sasaki Y, Calado DP, Derudder E, Zhang B, Shimizu Y, Mackay F, Nishikawa S, Rajewsky K, Schmidt-Supprian M. NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10883-8. doi: 10.1073/pnas.0805186105 . Epub 2008 Jul 28. PubMed PMID: 18663224 ; PubMed Central PMCID: PMC2504772.
Wunderlich FT, Luedde T, Singer S, Schmidt-Supprian M, Baumgartl J, Schirmacher P, Pasparakis M, Brüning JC. Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1297-302. doi: 10.1073/pnas.0707849104 . Epub 2008 Jan 23. PubMed PMID: 1821626 3; PubMed Central PMCID: PMC2234132.
Schmidt-Supprian M, Rajewsky K. Vagaries of conditional gene targeting. Nat Immunol. 2007 Jul;8(7):665-8. Review. PubMed PMID: 17579640 .
Greve B, Weissert R, Hamdi N, Bettelli E, Sobel RA, Coyle A, Kuchroo VK, Rajewsky K, Schmidt-Supprian M. I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. J Immunol. 2007 Jul 1;179(1):179-85. PubMed PMID: 17579036 .
Schmidt-Supprian M, Wunderlich FT, Rajewsky K. Excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination. Transgenic Res. 2007 Oct;16(5):657-60. Epub 2007 Jun 1. PubMed PMID: 17541717 .
Liu H, Schmidt-Supprian M, Shi Y, Hobeika E, Barteneva N, Jumaa H, Pelanda R, Reth M, Skok J, Rajewsky K, Shi Y. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev. 2007 May 15;21(10):1179-89. PubMed PMID: 17504937 ; PubMed Central PMCID: PMC1865490.
Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27;316(5824):604-8. PubMed PMID: 17463289 .
Ben-Neriah Y, Schmidt-Supprian M. Epithelial NF-kappaB maintains host gut microflora homeostasis. Nat Immunol. 2007 May;8(5):479-81. PubMed PMID: 17440457 .
Sasaki Y, Schmidt-Supprian M, Derudder E, Rajewsky K. Role of NFkappaB signaling in normal and malignant B cell development. Adv Exp Med Biol. 2007;596:149-54. Review. PubMed PMID: 17338183 .
Tsytsykova AV, Falvo JV, Schmidt-Supprian M, Courtois G, Thanos D, Goldfeld AE. Post-induction, stimulus-specific regulation of tumor necrosis factor mRNA expression. J Biol Chem. 2007 Apr 20;282(16):11629-38. Epub 2007 Feb 15. PubMed PMID: 17303559 .
van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M, Lassmann H, Prinz MR, Pasparakis M. Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol. 2006 Sep;7(9):954-61. Epub 2006 Aug 6. PubMed PMID: 16892069 .
Wegener E, Oeckinghaus A, Papadopoulou N, Lavitas L, Schmidt-Supprian M, Ferch U, Mak TW, Ruland J, Heissmeyer V, Krappmann D. Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell. 2006 Jul 7;23(1):13-23. PubMed PMID: 16818229 .
Sasaki Y, Derudder E, Hobeika E, Pelanda R, Reth M, Rajewsky K, Schmidt-Supprian M. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity. 2006 Jun;24(6):729-39. PubMed PMID: 16782029 .
Pasparakis M, Luedde T, Schmidt-Supprian M. Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice. Cell Death Differ. 2006 May;13(5):861-72. Review. PubMed PMID: 16470223 .
Nenci A, Huth M, Funteh A, Schmidt-Supprian M, Bloch W, Metzger D, Chambon P, Rajewsky K, Krieg T, Haase I, Pasparakis M. Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. Hum Mol Genet. 2006 Feb 15;15(4):531-42. Epub 2006 Jan 6. PubMed PMID: 16399796 .
Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005 Apr;115(4):849-59. Epub 2005 Mar 17. PubMed PMID: 15776110 ; PubMed Central PMCID: PMC1064982.
Sasaki Y, Casola S, Kutok JL, Rajewsky K, Schmidt-Supprian M. TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004 Aug 15;173(4):2245-52. PubMed PMID: 15294936 .
Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S, Coyle AJ, Rajewsky K. I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion. J Immunol. 2004 Aug 1;173(3):1612-9. PubMed PMID: 15265889 .
Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4566-71. Epub 2004 Mar 16. PubMed PMID: 15070758 ; PubMed Central PMCID: PMC384787.
Schmidt C, Peng B, Li Z, Sclabas GM, Fujioka S, Niu J, Schmidt-Supprian M, Evans DB, Abbruzzese JL, Chiao PJ. Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. Mol Cell. 2003 Nov;12(5):1287-300. PubMed PMID: 14636585 .
Schmidt-Supprian M, Courtois G, Tian J, Coyle AJ, Israël A, Rajewsky K, Pasparakis M. Mature T cells depend on signaling through the IKK complex. Immunity. 2003 Sep;19(3):377-89. PubMed PMID: 14499113 .
Pasparakis M, Schmidt-Supprian M, Rajewsky K. IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med. 2002 Sep 16;196(6):743-52. PubMed PMID: 12235208 ; PubMed Central PMCID: PMC2194059.
Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A, Krampert M, Goebeler M, Gillitzer R, Israel A, Krieg T, Rajewsky K, Haase I. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature. 2002 Jun 20;417(6891):861-6. PubMed PMID: 12075355 .
Schmidt-Supprian M, Murphy C, While B, Lawler M, Kapurniotu A, Voelter W, Smith O, Bernhagen J. Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes. Eur Cytokine Netw. 2000 Sep;11(3):407-13. PubMed PMID: 11022125 .
Schmidt-Supprian M, Bloch W, Courtois G, Addicks K, Israël A, Rajewsky K, Pasparakis M. NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol Cell. 2000 Jun;5(6):981-92. PubMed PMID: 10911992 .